Saturday, October 26, 2013

Researchers track lethal prostate cancer to determine clonal origin

Researchers track lethal prostate cancer to determine clonal origin


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PUBLIC RELEASE DATE:

25-Oct-2013



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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation






Prostate cancer has variable manifestations, ranging from relatively benign localized tumors to widespread life-threatening metastases. The origin of most prostate cancer metastases can be traced back to the primary tumor; therefore, understanding the mutations in the primary tumor that promote cancer spread is of great interest. In this issue of the Journal of Clinical Investigation, Srinivasan Yegnasubramanian and colleagues at Johns Hopkins University track the development of lethal prostate cancer in a patient. Using tissue samples taken throughout the progression of the cancer, the authors identified the origin of the lethal clone. Surprisingly, in this case the lethal clone originated from a small, low-grade foci in the primary tumor and not from the larger high-grade region of the tumor. In the accompanying commentary, Rose Brannon and Charles Sawyers of Memorial Sloan-Kettering Cancer Center discuss the importance of individual case studies and how a comprehensive database of such studies is needed to identify common patterns in cancer progression.

###

TITLE:
Tracking the clonal origin of lethal prostate cancer

AUTHOR CONTACT:
Michael C. Haffner

Johns Hopkins Medical Institutions, Baltimore, MD, USA

Phone: 4106142676; Fax: ; E-mail: michael.c.haffner@gmail.com

View this article at: http://www.jci.org/articles/view/70354?key=4f436390394081ee2a50

ACCOMPANYING COMMENTARY

TITLE:
"N of 1" case reports in the era of whole-genome sequencing

AUTHOR CONTACT:
Charles Sawyers

Memorial Sloan-Kettering Cancer Center, New York, NY, USA

Phone: 646-888-2138; Fax: ; E-mail: sawyersc@mskcc.org

View this article at: http://www.jci.org/articles/view/70935?key=0fe6ce6bb3bf4e8a509a



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Researchers track lethal prostate cancer to determine clonal origin


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

25-Oct-2013



[


| E-mail

]


Share Share

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation






Prostate cancer has variable manifestations, ranging from relatively benign localized tumors to widespread life-threatening metastases. The origin of most prostate cancer metastases can be traced back to the primary tumor; therefore, understanding the mutations in the primary tumor that promote cancer spread is of great interest. In this issue of the Journal of Clinical Investigation, Srinivasan Yegnasubramanian and colleagues at Johns Hopkins University track the development of lethal prostate cancer in a patient. Using tissue samples taken throughout the progression of the cancer, the authors identified the origin of the lethal clone. Surprisingly, in this case the lethal clone originated from a small, low-grade foci in the primary tumor and not from the larger high-grade region of the tumor. In the accompanying commentary, Rose Brannon and Charles Sawyers of Memorial Sloan-Kettering Cancer Center discuss the importance of individual case studies and how a comprehensive database of such studies is needed to identify common patterns in cancer progression.

###

TITLE:
Tracking the clonal origin of lethal prostate cancer

AUTHOR CONTACT:
Michael C. Haffner

Johns Hopkins Medical Institutions, Baltimore, MD, USA

Phone: 4106142676; Fax: ; E-mail: michael.c.haffner@gmail.com

View this article at: http://www.jci.org/articles/view/70354?key=4f436390394081ee2a50

ACCOMPANYING COMMENTARY

TITLE:
"N of 1" case reports in the era of whole-genome sequencing

AUTHOR CONTACT:
Charles Sawyers

Memorial Sloan-Kettering Cancer Center, New York, NY, USA

Phone: 646-888-2138; Fax: ; E-mail: sawyersc@mskcc.org

View this article at: http://www.jci.org/articles/view/70935?key=0fe6ce6bb3bf4e8a509a



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/joci-rtl101813.php
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